The William Dunlap Simpson House, located at 726 West Main Street in Laurens, South Carolina, is a significant example of Greek Revival architecture and holds considerable historical importance due to its association with prominent figures in South Carolina’s history.​

• Construction: Built in 1839 by Christopher Garlington, likely utilizing architectural pattern books of the era.
• Structure: A three-story, white clapboard dwelling comprising twelve rooms.
• Chimneys: Features five chimneys—four integrated within the end walls and a fifth in the rear projection.
• Columns: Adorned with two pairs of fluted Doric columns, characteristic of the Greek Revival style. ​

The house gained prominence when William Dunlap Simpson acquired it after the Civil War. Simpson was a distinguished lawyer and politician who served as:​

• A member of the South Carolina House of Representatives and State Senate.
• A Confederate Congressman during the Civil War.
• The 78th Governor of South Carolina (1879–1880).
• The Chief Justice of the South Carolina Supreme Court (1880–1890). ​

The residence remained in the Simpson family until 1939, when it was sold to the Motes family.

The William Dunlap Simpson House was added to the National Register of Historic Places on July 24, 1974, and is a contributing property within the Laurens Historic District, which encompasses a variety of structures built between 1880 and 1940.