Scaife-Perrin House, located at 417 East Main Street in Union, South Carolina, is a historic residence constructed circa 1880. The house underwent significant alterations around 1900, reflecting the architectural trends of that period. It is a contributing property within the East Main Street–Douglass Heights Historic District, which was added to the National Register of Historic Places in 1989.

The Scaife-Perrin House is a two-story weatherboard residence with notable architectural elements, including:

• A two-story rectangular bay on the left façade
• A one-story porch with Doric columns
• A hipped roof

These features contribute to the house’s distinctive appearance within the historic district.

The residence was built for William Scaife, a prominent figure in Union County. Scaife was a well-known Baptist minister who served as the pastor of Lower Fairforest Church for many years. He also organized Beulah Baptist Church and served as its pastor. In 1883, Scaife left Union County and moved to Fair Forest, later relocating to Woodruff, and eventually to Campobello to spend his declining years.

The house was later owned by the Perrin family, with George O. Perrin, Jr. spending time in Union with his parents in the early 1900s.

As a private residence, the Scaife-Perrin House is not open to the public. However, its architectural features can be appreciated from the street. Visitors are encouraged to view the exterior respectfully from public sidewalks or roads.