The R.L. Nimmons House in Seneca, South Carolina, is a notable historic residence located at 110 S. Townville Street. It is part of the Seneca Historic District, which was listed on the National Register of Historic Places on December 31, 1974, with a boundary increase on April 23, 1987.

The house is an example of Late Victorian architecture, characterized by its asymmetrical design, decorative trim, and complex rooflines. While specific details about the house’s architectural features are not readily available, it is situated in a district that includes a variety of architectural styles, such as Victorian, Classical Revival, Bungalow, Tudor Revival, and Four-Square.

The Seneca Historic District is significant for its association with the development of Seneca as a center of commerce in the late 19th and early 20th centuries. Many of the structures in the district belonged to leading families of early Seneca, reflecting the town’s growth during this period.