The Poe House in Pendleton, South Carolina, is a historic residence constructed in 1860 by Mrs. Ellen Taylor Poe, a widow who returned to Pendleton with her young children following the death of her husband. Her late husband was a second cousin to the renowned poet Edgar Allan Poe .​

The Poe House is a two-story, wood-frame dwelling featuring elements typical of mid-19th-century Southern architecture. While specific architectural features are not detailed in the available sources, the house’s design reflects the period’s emphasis on functionality and modest elegance.​

The Poe House is situated in the Pendleton Historic District, a region recognized for its well-preserved 18th and 19th-century architecture. This district is listed on the National Register of Historic Places and encompasses over 6,000 acres, showcasing more than 40 points of historic interest .​