Old Stone Church is a church building built in 1802. When it was constructed, it was in the Pendleton District, South Carolina. When Pendleton District was divided in 1826, the church was in Pickens District. When Pickens District was split in 1868, it was in Oconee County, South Carolina. In 1968, this section of Oconee County was annexed back to Pickens County. The church is about midway between the centers of Pendleton and Clemson. It is now in the city limits of Clemson.