The Lyde Irby Darlington House, also known as the Monroe House, is a historic residence located at 110 Irby Avenue in Laurens, South Carolina. Built around 1899, this two-story frame dwelling showcases an eclectic blend of architectural styles, including Queen Anne, Eastlake, and Classical Revival. Notable features of the house include polygonal bays and a wraparound porch, which contribute to its distinctive character. In recognition of its architectural significance, the house was added to the National Register of Historic Places on November 19, 1986 .

The house was originally constructed for Lyde Irby Darlington, a prominent figure in the Laurens community. Over the years, the residence has been well-preserved, maintaining much of its original charm and architectural integrity.​

While the house is a private residence and not open to the public, it can be appreciated from the street as part of the Laurens Historic District. Visitors to Laurens interested in historic architecture may find the Lyde Irby Darlington House a noteworthy example of late 19th-century residential design.