The Lowndes Plantation House is a significant example of antebellum Southern plantation architecture, reflecting the refined domestic building traditions of the Upstate during the early- to mid-19th century. The house embodies characteristics of the Greek Revival style, popular in the region during this period, and demonstrates the integration of classical design principles with the functional requirements of a working plantation residence.

The plantation house is a two-story, timber-framed structure set upon a raised brick or stone foundation, which elevates the living spaces above the ground to protect against moisture and flooding while providing a sense of prominence. The façade is symmetrically arranged, typically featuring a central entrance flanked by evenly spaced windows. A full-width or recessed front porch, supported by square or Doric columns, emphasizes the classical inspiration of the design while providing shaded outdoor living space appropriate to the Southern climate.

The roof is a low-pitched gable or hipped form, often with wide overhanging eaves and simple cornice detailing. Exterior walls are clad in horizontal weatherboard siding, painted to unify the façade and highlight the clean lines of the architectural composition. Fenestration consists of tall, double-hung sash windows, sometimes with six-over-six or nine-over-nine pane configurations, maintaining the symmetry and proportion central to Greek Revival design. The central doorway is frequently accentuated with transom and sidelights, reflecting both stylistic refinement and practical considerations for natural light and ventilation.

Interior spaces follow a center-hall or side-hall plan, with formal parlors and dining rooms located near the entrance and private family chambers toward the rear and upper floors. Original woodwork, including molded door and window surrounds, baseboards, mantels, and staircase details, exemplifies skilled craftsmanship while maintaining the restrained elegance characteristic of plantation houses of the period. Wide plank floors and high ceilings enhance both circulation and interior comfort, while the layout accommodates both family life and the social functions expected of a prominent plantation household.

The Lowndes Plantation House is significant under Criterion C for its architectural distinction as a well-preserved example of Greek Revival plantation architecture in the Upstate region. The building exemplifies the classical proportions, symmetry, and craftsmanship associated with antebellum Southern domestic design, while also illustrating the practical adaptations of plantation houses to climate and site. The house retains a high degree of integrity of location, design, materials, workmanship, and setting, offering a tangible representation of plantation-era life and architectural traditions in South Carolina.