Lott’s Tavern & Post Office was a significant historical site located in Johnston, South Carolina, in Edgefield County. Established around 1770, it began as a one-room log house built by Emsley Lott. Over time, the structure was expanded into a tavern serving travelers along the Columbia Road. In 1839, Lott’s son, John, added a front room to the tavern and became the first postmaster, establishing the first post office in what is now Johnston. The building stood until it was demolished in 1918. ​

The historical marker commemorating Lott’s Tavern & Post Office is located at the intersection of Calhoun Street (SC Highway 23) and Monument Drive in Johnston, SC. The marker was installed in 2001 by the Ridge Heritage Association. ​