The Limestone Springs Historic District includes ten buildings and one site associated with Limestone College and the community of Limestone Springs. The district is a significant collection of properties reflecting the history of the area in the nineteenth and early twentieth centuries as a popular resort, as a center of lime production, and as a center of female education. The focal point of the district is the historic section of Limestone College campus, which contains nine buildings constructed between ca. 1837 and 1941. The buildings on the campus are oriented towards a central lawn and fountain. The buildings are classically inspired and include architectural styles such as Gothic Revival and Neo-Classical and also a meeting house form church. Also included in the district is a limestone quarry that was mined in the nineteenth and early twentieth century and a mid-nineteenth century church building. The limestone quarry is located adjacent to the historic section of the campus and the Limestone Springs Baptist Church is adjacent to the quarry. Listed in the National Register May 27, 1986.