The Kershaw Depot, constructed in 1926 by the Southern Railway on Cleveland Street in Kershaw, is a well-preserved example of small-town railroad architecture of the early twentieth century. The depot replaced an earlier passenger and freight station and cotton platform destroyed by fire in 1926. Designed in the practical architectural tradition used by the Southern Railway, the building reflects the standardized yet distinctive character of railroad facilities that served communities throughout the Southeast. Its construction came during an important period in Kershaw’s development as a regional agricultural and industrial center.

Primarily a passenger station, the Kershaw Depot also handled freight, particularly cotton and products from nearby farms, textile operations, and cotton-oil mills. Its interior originally included a central ticketing area flanked by separate white and African American waiting rooms, reflecting the segregated transportation system of the era. The Southern Railway sold the building in 1945, after which it was adapted for commercial uses. Listed in the National Register of Historic Places in 1990, the depot remains an important reminder of the role rail transportation played in the growth and economic life of Kershaw and Lancaster County.