The Keowee Town Historical Marker commemorates a significant Cherokee settlement that once thrived in what is now Oconee County, South Carolina. Erected in 2006 by the Wizard of Tamassee Chapter of the Daughters of the American Revolution and the Oconee County Arts and Historical Commission, the marker is located near Salem at the intersection of Nimmons Bridge Road (State Highway S37-128) and Keowee Town Landing Road (State Highway S 37-98) .​

Keowee Town, meaning “mulberry grove place,” was the largest and most important of the Cherokee “Lower Towns” in South Carolina. Situated approximately one mile east of the marker’s location on the Keowee River, it was already a significant Cherokee town by 1721, serving as a major hub on the main trading path between the British and the Cherokees .​

In 1752, amid conflicts with the Creek Nation, most Cherokees left Keowee but requested the British to build Fort Prince George across the river, which was constructed between 1753 and 1754. Keowee was abandoned in 1760 during the Cherokee War but was later resettled. However, in 1776, during the American Revolution, Major Andrew Williamson’s South Carolina militia burned Keowee and other Lower Towns. The sites of the town and fort were eventually submerged in 1971 with the creation of Lake Keowee .