The John Payne House, located at 112 Calhoun Street in Johnston, South Carolina, is a notable example of late 19th-century residential architecture. Constructed around 1883, this one-and-a-half-story, weather boarded residence features a gable roof and three gabled dormers. The front porch is supported by turned posts and includes a turned balustrade, sawn frieze, and brackets, reflecting the decorative elements characteristic of the period.

This house is part of the Johnston Historic District, which was added to the National Register of Historic Places in 1982. The district encompasses a collection of well-preserved buildings that showcase the architectural styles prevalent in the late 19th and early 20th centuries.

The John Payne House stands as a testament to the architectural heritage of Edgefield County and offers insight into the residential designs of the era.