The John C. Calhoun Hotel was a historic landmark located at 402 North Main Street in Anderson, South Carolina. Constructed in 1925, it was designed by architects James J. Baldwin and James H. Casey, and built by the Fiske-Carter Construction Company, one of the largest contractors in the state during the 1920s . The hotel was established to promote business in the downtown area and stands as an example of early 20th-century hotels .​

Listed on the National Register of Historic Places, the building has been meticulously restored to its original splendor, retaining its classic styling while being updated with modern amenities. Today, it operates as The Calhoun, offering luxury downtown condos and apartments. Features include private gated parking, secure building access, a fully restored 4,000+ square foot lobby for residents’ use and entertaining, high-speed elevators, a fully equipped 24-hour fitness room, and more .​

An interesting fact about The Calhoun is that its lobby was used in the filming of Leatherheads, a 2008 film starring George Clooney, Renée Zellweger, and John Krasinski .