Seay House, also known as the Jammie Seay House, is a historic log cabin located at 106 Darby Road in Spartanburg, South Carolina. Believed to be the oldest house within the city’s limits, it was constructed between 1770 and 1800. The cabin is a one-story, one-and-a-half-story structure with a loft, featuring hand-hewn logs, a fieldstone foundation, and a distinctive fieldstone chimney—a style uncommon in Upstate South Carolina but typical of Virginia architecture .​

The house was built by Jammie Seay, a Revolutionary War soldier who served in the Second Virginia Infantry. After the war, he settled in South Carolina, acquiring land near Fairforest Creek in 1784. The Seay family remained in the home for several generations, with Kinsman Seay, Jammie’s son, being the last direct descendant associated with the house until around 1969.

The Seay House offers insight into early rural life in Spartanburg, showcasing the architecture and lifestyle of the period. It was added to the National Register of Historic Places on October 7, 1971.​