The Irby-Henderson-Todd House is a historic residence located at 112 Todd Avenue in Laurens, South Carolina. Constructed around 1838, the house underwent significant expansions in 1855 and 1880, evolving from a modest antebellum farmhouse into a stately Classical Revival mansion with Victorian influences. Notable architectural features include a prominent two-story pedimented portico, reflecting its architectural evolution over time .​

The house is named after three prominent figures: James H. Irby, William B. Henderson, and Rutherford B. Todd. James H. Irby was a significant political figure in South Carolina during the 19th century, serving in various legislative roles and as lieutenant governor from 1852 to 1854. He was also a plantation owner with substantial landholdings and enslaved laborers .​

The Irby-Henderson-Todd House was added to the National Register of Historic Places in 1983, recognized for its architectural significance and its association with notable local figures .​

As of the latest available information, the Irby-Henderson-Todd House is a private property and is not open to the public for tours. However, its historical and architectural significance makes it a noteworthy site for those interested in the history of Laurens and South Carolina.​