Hopkins Presbyterian Church, constructed circa 1891 in the Hopkins community of Richland County, is an unusually intact example of a small late-nineteenth-century rural church. Originally built for the Hopkins Methodist congregation, the one-story frame building is sheathed in weatherboard siding and rests on brick piers beneath a longitudinal gable roof. Its modest façade features a small gabled vestibule with an arched entrance, six-over-six sash windows, and distinctive imbricated and squared shingles in the gable ends. A tripartite window on the rear elevation provides an especially notable architectural feature, while the simple interior retains beaded-board walls and ceiling.

The building became associated with the Hopkins Presbyterian congregation in 1919 after the Methodist congregation had lapsed. The Presbyterian congregation had originated as a small group meeting in a nearby schoolhouse, with a student from Columbia Theological Seminary preaching to the group twice each month before its formal organization in 1916. The sanctuary retains original furnishings including wooden pews, pulpit chairs, a lectern, communion table, and pump organ, while the surrounding cemetery reinforces the property’s longstanding religious and community associations. Hopkins Presbyterian Church was listed in the National Register of Historic Places in 1986 for its architectural and religious significance.