Guy H. Wilburn House is a historic residence located at 603 East Main Street in Union, South Carolina. Constructed around 1915, this home is a contributing property within the East Main Street–Douglass Heights Historic District, which was added to the National Register of Historic Places in 1989.

The house is associated with Guy Hollis Wilburn (1890–1962), a notable figure in Union County. Wilburn was active in the local community and is remembered for his contributions to the area’s civic life.

The East Main Street–Douglass Heights Historic District encompasses a range of architectural styles from the late 19th and early 20th centuries, reflecting the residential development of Union during that period. The district includes notable dwellings such as the Steadman-Nicholson House, Laurens G. Young House, and William H. Wallace House.

Please note that the Guy H. Wilburn House is a private residence. Visitors are encouraged to view it respectfully from public sidewalks or roads.