The Greer Post Office, located at 106 South Main Street in downtown Greer, South Carolina, is a distinguished example of Colonial Revival architecture from the New Deal era. Constructed in 1935 under the Public Works Administration, the building was designed by New York City architect Donald G. Anderson, with Louis A. Simon serving as the supervising architect.

This historic structure was added to the National Register of Historic Places on January 31, 2011, recognizing its architectural significance and role in the community’s development.

In 2008, the building was repurposed to house the Greer Heritage Museum, which showcases the region’s rich history, including exhibits on agriculture, textiles, and local culture.

A notable feature of the interior is the mural “Cotton and Peach Growing”, painted in 1940 by artist Winfield Walkley as part of a federal arts initiative. The mural depicts the region’s agricultural heritage and was restored after being covered during the building’s use as city hall.

The Greer Post Office stands as a testament to the community’s history and architectural heritage, offering visitors a glimpse into the past while serving as a center for local culture and education.