Charlton Rauch House is a historic home located at Lexington, Lexington County, South Carolina. It was built in 1886, and is a 2+¹⁄₂-story, frame vernacular Queen Anne style house with an irregular plan and a gable roof. It is sheathed in weatherboard and has a one-story rear wing. The front façade features a one-story, hip roofed porch with a second-story, shed-roofed porch; a two-story polygonal bay; and a hip-roofed, three-story, projecting polygonal bay. Its owner Charlton Rauch operated a livery stable and was a cotton buyer and dealer in general merchandise.

It was listed on the National Register of Historic Places in 1983.