The Chamberlain-Kay House, located at 205 River Street in Belton, South Carolina, is one of the oldest surviving residences in the town, with its construction dating back to around 1854. Built for Charles C. Chamberlain, the first supervisor of the rail line from Belton to Greenville and the town’s first intendant (mayor) upon its incorporation in 1855, the house holds significant historical value.

The house is a compelling example of evolving architectural styles, showcasing a blend of:​

 Greek Revival: Notable in the doorway’s transom, sidelights, and anthemion ornamentation.

• Carpenter Gothic: Evident in the original board and beveled batten siding, bargeboards, and brackets.
• Queen Anne: Reflected in the metal shingles on the roof and cedar shingles on the second story.

Originally designed in the Piedmont Farmhouse or I-House style, the structure has undergone several modifications over the years, resulting in an amalgamation of these architectural elements. ​

 1854: Constructed for Charles C. Chamberlain.

• 1860: Purchased by Ira Williams, a figure active in Democratic politics; the house served as a venue for political rallies.
• 1946: Acquired by Judge William P. Kay; his wife, Alice Kay, operated the town’s kindergarten from the residence.
• 1911–1922: The house was reoriented to face River Street, altering its original orientation.
• 1980: Listed on the National Register of Historic Places on November 25. ​
•  The Chamberlain-Kay House is a private residence and is not open to the public. However, a historical marker, installed in 2015 by the Kay Family Association and the Belton Area Museum Association, is located at the intersection of River Street (State Highway 247) and William Street. This marker provides insights into the home’s history and significance.