Van Wyck Presbyterian Church, located on Old Hickory Road in Van Wyck, Lancaster County, South Carolina, traces its origins to 1884, when a small congregation gathered under the oak trees of the Crenshaw Plantation and petitioned Bethel Presbytery to establish a church. Originally organized as Beulah Presbyterian Church, the congregation served the surrounding rural farming community and became an important center of religious and social life. Following the establishment of the Seaboard Railroad and the development of the nearby village of Van Wyck in the late 1880s, the congregation continued to grow, reflecting the changing settlement patterns and community development of northern Lancaster County.
The original church building, constructed circa 1884, was replaced in 1911–1912 when the congregation relocated to Van Wyck and adopted its present name. The current historic sanctuary is a one-story rectangular brick building featuring a simple, traditional church design that emphasizes symmetry, durability, and function. Its construction is attributed to Julian S. Starr, a Rock Hill contractor and architect, and it reflects the early twentieth-century growth of the community. The congregation has continued to serve the area through subsequent changes, including the addition of an educational building in 1940–1941 and a fellowship hall in 2009. Van Wyck Presbyterian Church remains an important landmark in the religious and community history of Lancaster County.