The Mrs. G.W. Gignilliat House is a historic residence located at 315 S. First Street in Seneca, South Carolina. It is part of the Seneca Historic District, which was listed on the National Register of Historic Places on December 31, 1974, with a boundary increase on April 23, 1987.

This district showcases a variety of architectural styles, including Victorian, Classical Revival, Bungalow, Tudor Revival, and Four-Square, reflecting the growth and development of Seneca during the late 19th and early 20th centuries.

 The Gignilliat family, including George Warren Gignilliat, played a significant role in Seneca’s development, particularly in the cotton industry and local commerce. The Mrs. G.W. Gignilliat House contributes to the architectural and historical fabric of the district, representing the affluence and influence of the Gignilliat family in the region.